Expression of collagenases (matrix metalloproteinase-1, 8, 13) and tissue inhibitor of metalloproteinase-1 of retrodiscal tissue in temporomandibular joint disorder patients
고원경, 최유리, 박광호, 허종기,
소속 상세정보
고원경 ( Gho Won-Gyung ) - Myongji Hospital Department of Dentistry
최유리 ( Choi Yu-Ri ) - Yonsei University College of Dentistry Department of Oral and Maxillofacial Surgery
박광호 ( Park Kwang-Ho ) - Yonsei University College of Dentistry Department of Oral and Maxillofacial Surgery
허종기 ( Huh Jong-Ki ) - Yonsei University College of Dentistry Department of Oral and Maxillofacial Surgery
Abstract
Objectives: The aim of this study was to reveal how collagenases (matrix metalloproteinase [MMP]-1, 8, 13) and tissue inhibitor of metalloproteinase 1 (TIMP-1) are expressed in immunohistochemistry of retrodiscal tissue in temporomandibular joint disorder patients.
Materials and Methods: This study was conducted on 39 patients who underwent discoplasty or discectomy. Immunohistochemical staining was undertaken and expression levels of MMP-1, 8, 13, and TIMP-1 were evaluated. The status of internal derangement of disc, osteoarthritis, and joint effusion were analyzed using magnetic resonance imaging (MRI). Disc status observed during operation was also categorized.
Results: The more severe disc derangement was observed on MRI, the more increased expression of MMPs and TIMP-1 appeared. Regarding MMP-13 expression, 86.7% of late-stage disc displacement patients showed grade II or III. Expression level of MMPs or TIMP was not statistically significant associated with joint effusion level. In perforation and/or adhesion groups, all patients showed grade II or III expression of MMP-13. Once perforation occurred, MMP-13 showed increased expression with statistical significance.
Conclusion: MMP-1 and MMP-13 expression seem to be related to progression of osteoarthritis whereas MMP-8 does not seem to have a specific role with regard to temporomandibular joint disorders. TIMP-1 is considered to be partly related to internal derangement rather than osteoarthritis, but it is not significant.
키워드
Collagenases; Matrix metalloproteinase; Tissue inhibitor of metalloproteinase; Temporomandibular joint disorders; Immunohistochemistry
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